Inositol phosphate and Ca2+ flow
نویسندگان
چکیده
منابع مشابه
Phosphatidylinositol and inositol phosphate metabolism.
The six carbons that comprise the inositol ring can be phosphorylated in a combinatorial manner, generating a truly astonishing range of inositol phosphates and inositol lipids. Yet, somehow, the cell can distinguish and utilize several of these metabolites to specifically regulate a variety of signal transduction processes. These important actions have infiltrated so many areas of cell biology...
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Cytotoxic ether lipid analogues have been studied for their ability to inhibit growth factor-dependent [Ca2+]i signaling in Swiss 3T3 fibroblasts. 1-Octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) inhibited 45Ca2+ uptake and inositol(1,4,5)trisphosphate-induced 45Ca2+ release in saponin permeabilized cells with concentration producing 50% inhibition values of 55 and 360 microM, res...
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Cytotoxic ether lipid analogues have been studied for their ability to inhibit growth factor-dependent |< ¡r'*| signaling in Swiss 3T3 fibroblasts. l -Octadecyl^-methyl-rac-glycero-S-phosphocholine (ET-18-OCH3) in hibited 4<<V+ uptake and inositol(l,4,5)trisphosphate-induced "Ça2* release in saponin permeabilized cells with concentration producing 50% inhibition values of 55 and 360 UM,respec...
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The action of adenine and uracyl nucleotides on rat brain capillary endothelial cells was investigated. ATP, UTP, and adenosine 5'-O-(3-thiotrisphosphate) activated phospholipase C and induced large increases in [Ca2+]i. ADP had a different action. At low concentrations (< 10 microM), ADP induced the mobilization of a thapsigargin-sensitive intracellular Ca2+ store in the absence of measurable ...
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ژورنال
عنوان ژورنال: Nature
سال: 1990
ISSN: 0028-0836,1476-4687
DOI: 10.1038/343701b0